Fucoidan attenuates age-related skeletal muscle atrophy via gut microbiota-dependent tryptophan metabolic Remodeling.

Pengfei Ren, Meng Liu, Biqian Wei, Wanting Qin, Hui Qi

Translational Medicine Research Center, Shanxi Medical University, PR China; State Key Laboratory of Marine Food Processing &Safety Control, College of Food Science and Engineering, Ocean University of China, PR China. Electronic address: [email protected]. · pubmed

Paper

Abstract

Age-related skeletal muscle atrophy poses significant health challenges in the elderly. The gut-muscle axis has emerged as a critical regulator of muscle homeostasis, and dietary interventions targeting gut microbiota show promise. Fucoidan, a sulfated polysaccharide from marine algae, exhibits prebiotic and anti-aging properties, but its effects on age-related skeletal muscle atrophy remain unexplored.

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Research summary

Fucoidan may mitigate age-related skeletal muscle atrophy through modulation of gut microbiota and tryptophan metabolism. This research addresses a significant aspect of aging by exploring dietary interventions that could influence muscle health, which is crucial for longevity.

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