Rhapontigenin alleviates cellular senescence and physiological aging by upregulating sirt1 and promoting autophagy.

Shuang Liu, Wendi Chen, Guoqiang Xu, Xin Liu, Yuxuan Shi, Guolong Wang, Yunna Ning, Yongzhi Cao, Ming Li, Yueran Zhao

State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, China. · pubmed

Paper

Abstract

Aging is characterized by cellular senescence, inflammation, and physiological decline. Currently available antiaging therapies often have limitations due to their toxicity and off-target effects. However, natural compounds derived from Chinese herbal medicine, such as Rhapontigenin (Rhap), have shown potential as safer antiaging agents.

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Research summary

Rhapontigenin alleviates cellular senescence and physiological aging by upregulating sirt1 and promoting autophagy. The paper addresses the root causes of aging by exploring a natural compound that may mitigate cellular senescence and promote longevity-related mechanisms.

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