Polygonatum polysaccharide improves cognitive function in senescence-accelerated mice by regulating ferroptosis through the cAMP/PKA/CREB pathway: transcriptomics-based and in vivo experimental validation.

Lan Xiao, Yin OuYang, Yan Fu, Jian Yi, Bowei Chen, Sha Peng, Fanzuo Zeng, WenFang Zhang, Baiyan Liu

Faculty of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China.Faculty of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China. · pubmed

Paper

Abstract

Cognitive decline is a core feature of aging and related neurodegenerative diseases. Polygonatum odoratum, a traditional Chinese medicine used to tonify qi and nourish yin, is a classic herbal remedy for cognitive impairment. Its active component, Polygonatum polysaccharide (POP), exhibits antioxidant and anti-aging potential. Our group's prior research demonstrated that POP could improve age-related cognitive decline. The pathogenesis of cognitive impairment is closely linked to the activation of neuronal ferroptosis, making targeted inhibition of neuronal ferroptosis a highly promising new approach for intervening in cognitive decline. Against this backdrop, whether and how POP suppresses ferroptosis to improve cognitive function warrants attention.

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Research summary

Polygonatum polysaccharide improves cognitive function in senescence-accelerated mice by regulating ferroptosis through the cAMP/PKA/CREB pathway. The paper addresses cognitive decline, a core feature of aging, and explores a potential mechanism (ferroptosis regulation) that could contribute to interventions targeting the underlying processes of aging.

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