Intrinsic capacity-frailty phenotypes and subclinical inflammation in community-dwelling octogenarians: A cross-sectional analysis from the ilSIRENTE study.

Stefano Cacciatore, Riccardo Calvani, Konstantinos Prokopidis, Mathias Schlögl, Andrea Russo, Matteo Tosato, Stephen D Anton, Christiaan Leeuwenburgh, John A Batsis, Emanuele Marzetti, Francesco Landi

Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy; Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy; Department of Physiology & Aging, College of Medicine, University of Florida, Gainesville, FL, United States. Electronic address: [email protected]. · pubmed

Paper

Abstract

Chronic low-grade inflammation contributes to frailty and functional decline in aging. Intrinsic capacity (IC), defined as the composite of physical and mental reserves, complements frailty assessment by reflecting functional resilience. This cross-sectional analysis used baseline data from the ilSIRENTE cohort to examine the relationship between IC-frailty phenotypes and systemic inflammation in community-dwelling octogenarians and identify IC domains most closely related to inflammatory burden.

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Research summary

The paper examines the relationship between intrinsic capacity-frailty phenotypes and systemic inflammation in octogenarians. This research is relevant as it explores factors contributing to functional resilience and frailty, which are critical in understanding the aging process and potential interventions for age-related decline.

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