Active Vitamin D Insufficiency Accelerates Skeletal Aging via Oxidative Stress and p16-Mediated Senescence.

Wanxin Qiao, Mingxin Huang, Lulu Chen, David Goltzman, Dengshun Miao

The Research Center for Bone and Stem Cells, Department of Anatomy, Histology and Embryology, Nanjing Medical University, 211166 Nanjing, Jiangsu, China.The Research Center for Bone and Stem Cells, Department of Anatomy, Histology and Embryology, Nanjing Medical University, 211166 Nanjing, Jiangsu, China. · pubmed

Paper

Abstract

Vitamin D is essential for skeletal health, but its role in redox homeostasis and cellular senescence during aging

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Research summary

Active Vitamin D insufficiency accelerates skeletal aging through oxidative stress and p16-mediated senescence. This paper addresses the role of Vitamin D in cellular senescence and oxidative stress, which are key factors in the aging process and longevity research.

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