Renal podocyte senescence in human obesity detected by urinary extracellular vesicles.

Lei Zhang, Mina Al-Saeedi, Aleksandar Denic, Kyra L Jordan, Ning Yang, Fei Yuan, Xiangyang Zhu, Ailing Xue, Hui Tang, Alfonso Eirin, Amir Lerman, Mary Fidler, LaTonya J Hickson, Andrew D Rule, Aleksandra Kukla, Lilach O Lerman

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA; Department of Urology, Zhongda Hospital, Southeast University, Nanjing, China. · pubmed

Paper

Abstract

Obesity is a major risk factor for kidney dysfunction, with cellular senescence and senescence-associated secretory phenotype (SASP) activation contributing to early kidney injury. Urinary extracellular vesicles (uEVs) provide a non-invasive approach to assess cellular stress. We hypothesised that obesity induces podocyte senescence detectable by podocyte-derived uEVs.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that obesity induces podocyte senescence detectable by podocyte-derived urinary extracellular vesicles. This research is relevant as it explores the mechanisms of cellular senescence in the context of obesity, which is a significant factor in age-related kidney dysfunction, potentially addressing root causes of aging-related diseases.

Author of this paper? Send a correction.