Age-dependent effects of exercise on gut microbiota-mitochondria axis and cognitive function in aging mice.
Abstract
Aging is accompanied by progressive impairments in mitochondrial bioenergetics, apoptosis regulation, and gut microbiota homeostasis, all of which contribute to cognitive decline. In this study, we investigated whether the effects of treadmill exercise on the gut microbiota-mitochondrion-neuronal plasticity axis differed between young (15 months) and old (28 months) mice. Male C57BL/6 mice were randomly assigned to the following groups: early sedentary, early exercise, late sedentary, or late exercise groups and completed an 8-week treadmill training protocol. Cognitive function was assessed using the passive avoidance test and the Morris water maze test. Hippocampal mitochondrial respiration, Ca
The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.
Research summary
The paper claims that treadmill exercise differentially affects the gut microbiota-mitochondrion-neuronal plasticity axis and cognitive function in aging mice. This research addresses the interplay between exercise, gut microbiota, and mitochondrial function, which are all critical factors in the aging process and cognitive decline, thus contributing to our understanding of potential interventions for age-related decline.
Author of this paper? Send a correction.