AKG-TET axis is central to senescence plasticity.
Abstract
Cellular senescence, a state of stable cell-cycle arrest associated with aging, is characterized by a distinct pro-inflammatory secretome. This study systematically interrogates the critical role of the α-ketoglutarate (AKG)-Ten-eleven translocation (TET) axis in regulating senescence in human somatic cells. Downregulating
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Research summary
The paper claims that the AKG-TET axis plays a critical role in regulating cellular senescence. This research addresses mechanisms underlying cellular senescence, which is a fundamental aspect of aging and has implications for longevity and age-related diseases.
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