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RESEARCH PAPER / 2026-01-07

Baseline cardio-kidney-metabolic syndrome, its transition, and frailty: insights from the China Health and Retirement Longitudinal Study (CHARLS).

Ruixue Duan, Zhitong Li, Xuhui Li, Wenxia Ren, Jiaojiao Li, Yajing Bai, Angxian Lü, Yuanyuan Yan, Anqi Zhao, Shiwei Liu

Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China. · pubmed

Abstract

Cardio-kidney-metabolic (CKM) syndrome is a complex, multi-system health condition that affects aging populations, potentially contributing to frailty. This study aimed to examine the association between baseline CKM syndrome, its transitions over time, and the onset of frailty, using data from the China Health and Retirement Longitudinal Study (CHARLS).

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Research summary

The study examines the association between baseline cardio-kidney-metabolic syndrome and the onset of frailty in aging populations. This research is relevant as it explores a multi-system health condition that may contribute to frailty, which is a significant aspect of aging and longevity.

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