Endothelial ZBTB16: a molecular shield against cardiac aging.

Kathrin A Stilz, Vincent Elvin Leonard, David Rodriguez Morales, Simone-Franziska Glaser, Veronica Larcher, Mariano Ruz Jurado, Pedro Felipe Malacarne, Nivethitha Manickam, Lukas S Tombor, Wesley T Abplanalp, Josefine Panthel, Haris Kujundzic, Ariane Fischer, Katja Schmitz, Oliver J Müller, Susanne Hille, Christian Kupatt, Tarik Bozoglu, Haider Sami, Manfred Ogris, Tara Procida-Kowalski, Marek Bartkuhn, David John, Michail Yekelchyk, Tessa Schmachtel, Michael Rieger, Minh-Duc Pham, Jaya Krishnan, Stefan Günther, Ralf P Brandes, Thomas Braun, Andreas M Zeiher, Julian U G Wagner, Stefanie Dimmeler

Institute of Cardiovascular Regeneration, Goethe University Frankfurt, Theodor-Stern Kai 7, Building 25B, Frankfurt am Main 60590, Germany.Institute of Cardiovascular Regeneration, Goethe University Frankfurt, Theodor-Stern Kai 7, Building 25B, Frankfurt am Main 60590, Germany. · pubmed

Paper

Abstract

Aging significantly increases the risk of cardiovascular disease, characterized by progressive cardiac dysfunction. The vascular niche is crucial for maintaining cardiac homeostasis, yet endothelial cell (EC) impairment during aging remains poorly understood. This study investigates epigenetically regulated mechanisms underlying EC-dependent cardiac aging and identifies a critical role for zinc finger and BTB domain-containing protein 16 (ZBTB16).

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Research summary

The paper claims that ZBTB16 plays a critical role in regulating endothelial cell function to mitigate cardiac aging. This research addresses the underlying mechanisms of endothelial cell impairment in aging, which is essential for understanding and potentially intervening in the aging process and age-related cardiovascular diseases.

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