The effect of obesity and aging on NAD

Helena A K Lapatto, Birgitta W van der Kolk, Maheswary Muniandy, Sini Heinonen, Aino Heikkinen, Marcus Alvarez, Seung Hyuk T Lee, Riikka Jokinen, Jesper Lundbom, Juho Kuula, Antti Hakkarainen, Per-Henrik Groop, Jaakko Kaprio, Taru Tukiainen, Miina Ollikainen, Päivi Pajukanta, Eija Pirinen, Kirsi H Pietiläinen

Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland. [email protected] Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland. [email protected]. · pubmed

Paper

Abstract

The expression and/or activity of sirtuins (SIRTs), nicotinamide adenine dinucleotide (NAD

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that obesity and aging negatively affect NAD levels, which may influence sirtuin activity. This research is relevant as it addresses the biochemical mechanisms underlying aging and potential interventions that could mitigate age-related decline.

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