Estrogen receptor-autophagy axis protects the heart, aorta and kidneys during perimenopausal aging: Evidence from human cohort and mouse experiments.

Xiuting Xiang, Weizhou Jiang, Praneetha Palasuberniama, M Tanveer Hossain Parash, Rahmawati Pare, Yunjun Ruan

Department of Geriatrics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China; Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Malaysia.Department of Geriatrics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China; Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Malaysia. · pubmed

Paper

Abstract

The gradual decline in estrogen levels during perimenopause is strongly associated with an increased risk of metabolic and cardiovascular diseases. However, the specific relationship and underlying mechanisms remain incompletely understood. This study combines population data, network pharmacology, and mouse models to explore the detailed mechanisms underlying estrogen's organ-protective effects.

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Research summary

The study investigates the protective effects of estrogen on the heart, aorta, and kidneys during perimenopausal aging. This research is relevant as it explores mechanisms that could address age-related decline in organ function, contributing to our understanding of aging processes.

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