Human amniotic mesenchymal stem cell-derived extracellular vesicles improve oocyte quality and embryonic development by increasing antioxidant capacity in aged mice.

Boya La, Chunyan Jiang, Jia He, Man Ni, Jing Zhou, Huimin Wu, Song Ning, Wangjuan Dai, Zhengjie Yan, Yugui Cui, Lianju Qin, Jiayin Liu

State Key Laboratory of Reproductive Medicine and Offspring Health, Center of Clinical Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing, 210029, China. · pubmed

Paper

Abstract

Age-related decline in oocyte quality is a significant factor in reduced fertility. This study aimed to evaluate the role of human amniotic mesenchymal stem cell-derived extracellular vesicles (hAMSC-EVs) on oocytes in aged mice and to elucidate the underlying molecular mechanisms.

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Research summary

The paper claims that hAMSC-EVs improve oocyte quality and embryonic development in aged mice by increasing antioxidant capacity. This research addresses the decline in reproductive function associated with aging, which is a significant aspect of age-related biological decline.

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