A Histone Code Functionally Linked to Replicative Senescence.

Thomas Suter, Meyer J Friedman, Cagdas Tazearslan, Amir Gamliel, Daria Merkurjev, Kenneth Ohgi, Zhongjun Zhou, Michael G Rosenfeld, Yousin Suh

Cellular and Molecular Medicine, Department of Medicine, University of California San Diego, La Jolla, California, USA.Cellular and Molecular Medicine, Department of Medicine, University of California San Diego, La Jolla, California, USA. · pubmed

Paper

Abstract

Cell states and biological processes are defined by their epigenetic profiles, distinctive composites of DNA- and histone-based chromatin components. However, the specific histone posttranslational modifications that distinguish cellular senescence and the impact of their distribution on transcription, especially with regard to gene length, have not been fully elucidated. Here, we show that promoter loss of symmetric dimethylated H4R3 (H4R3me

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Research summary

The paper claims that specific histone posttranslational modifications, particularly the loss of symmetric dimethylated H4R3, are linked to cellular senescence and affect transcription. This research is relevant as it explores epigenetic mechanisms that could influence the aging process and cellular longevity, potentially addressing root causes of aging.

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