Perturbation of NAD(P)H metabolism with the

Shweta Yadav, Xingxiu Pan, Shengxi Li, Paige LaRae Martin, Ngoc Hoang, Kejin Chen, Aditi Karhadkar, Jatin Malhotra, Austin L Zuckerman, Subrata Munan, Markus K Klose, Lin Wang, Valentin Cracan, Andrey A Parkhitko

Aging Institute of UPMC, University of Pittsburgh, Pittsburgh, PA, USA.Aging Institute of UPMC, University of Pittsburgh, Pittsburgh, PA, USA. · pubmed

Paper

Abstract

Aging involves widespread metabolic dysregulation, including a decline in total nicotinamide adenine dinucleotide (NAD) levels. While NAD precursor supplementation elevates total NAD levels, it does not reveal tissue-specific effects of an altered NADH [reduced form of NAD

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the effects of NAD(P)H metabolism perturbation on aging-related metabolic dysregulation. This research is relevant as it addresses the decline in NAD levels, which is a key factor in the aging process and could provide insights into potential interventions for longevity.

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