Bidirectional associations between metabolic syndrome and epigenetic age acceleration: A 20-year longitudinal study in midlife adults.
Abstract
Metabolic syndrome (MetS) increases with age. Epigenetic alterations reflect lifelong biological and environmental influences on aging. MetS may contribute to epigenetic age acceleration (EAA) through inflammation and oxidative stress, while elevated EAA may, in turn, exacerbate metabolic dysfunction, but long-term evidence for this bidirectional association is limited.
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Research summary
The paper claims that there are bidirectional associations between metabolic syndrome and epigenetic age acceleration. This research is relevant as it explores the underlying mechanisms linking metabolic dysfunction and aging, potentially addressing root causes of age-related health issues.
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