Baicalein-manganese nanoparticles for antioxidant and osteogenic therapy of bone injury.

Ruqi Wang, Qishu Jin, Zhaoxu Meng, Xiaodong Cao, Yihao Wu, Chen Yang, Jiandong Yuan

School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China; Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China.School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China; Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China. · pubmed

Paper

Abstract

Oxidative stress is increasingly recognized as a key pathological driver of skeletal degeneration in diabetes, aging, trauma, and other orthopedic disorders, where excessive reactive oxygen species (ROS) compromise osteoblast and bone marrow mesenchymal stem cell (BMSC) function while promoting osteoclast activity. Natural polyphenols such as baicalein (BA) exhibit potent antioxidant effects but are hindered by poor solubility and limited stability. Here, we report a series of BA-X self-assembled nanoparticles, in which X represents osteogenic metal ions including Mg

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Research summary

The paper claims that baicalein-manganese nanoparticles can enhance antioxidant and osteogenic therapy for bone injury. The focus on oxidative stress and its role in skeletal degeneration aligns with addressing root causes of aging-related bone health issues.

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