Aging as a multifactorial disorder with two stages.

David Gems, Alexander Carver, Yuan Zhao

Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK. · pubmed

Paper

Abstract

Aging (senescence) is characterized by development of diverse senescent pathologies and diseases, leading eventually to death. The major diseases of aging, including cardiovascular disease, cancer and chronic obstructive pulmonary disease (COPD), are multifactorial disorders, resulting from complex interactions between multiple etiologies. Here we propose a general account of how different determinants of aging can interact to generate late-life disease. This account, initially drawn from studies of the nematode

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Research summary

The paper proposes a general account of how different determinants of aging interact to generate late-life disease. This research addresses the multifactorial nature of aging and its root causes, which is pertinent to longevity research.

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