Aging-associated immune signature as a predictor of mortality in end-stage renal disease: results from the longitudinal iESRD study.

Kai-Hsiang Shu, TienYu Owen Yang, Graham Pawelec, Feng-Jung Yang, Wan-Chuan Tsai, Yu-Sen Peng, Shih-Ping Hsu, Yi-Fang Chuang, Yen-Ling Chiu

Nephrology Division, Department of Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.Nephrology Division, Department of Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan. · pubmed

Paper

Abstract

Accelerated immune aging has been implicated in patients with end-stage kidney disease, but a detailed examination of immune profiles correlated with long-term outcomes for these individuals has never been performed. Therefore, we conducted a prospective observational study ("Immunity in end-stage renal disease", iESRD) to investigate the effects of immune aging on mortality among these patients. An exploratory panel of immune cell subsets was analyzed by flow cytometry at baseline (neutrophils, CD3-negative lymphocytes, CD4 and CD8 T cell differentiation stages, and three subsets of monocytes). Immune cell distribution patterns were identified through data-driven principal component analysis (PCA).

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Research summary

The paper claims that specific immune cell profiles can predict mortality in end-stage renal disease patients. This research is relevant as it explores the relationship between immune aging and mortality, addressing a potential underlying mechanism of aging-related health decline.

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