Obese plasma transfer accelerates cellular aging in the C57BL/6 mouse model.

Shabnam Shahabi Nejad, Hamid Zand, Samira Rastgoo, Leyli Zahra Bahreini Boroujeni, Mehdi Abedini Najafabadi, Saman Asadi, Reyhane Hamishe Bahar, Ghazaleh Shimi

Student Research Committee, Department of Cellular and Molecular Nutrition, Faculty of Nutrition Science and Food Technology, National Nutrition & Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Student Research Committee, Department of Cellular and Molecular Nutrition, Faculty of Nutrition Science and Food Technology, National Nutrition & Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. · pubmed

Paper

Abstract

Obesity induces chronic inflammation and cellular senescence, contributing to metabolic and immune dysfunction. This study investigates the effects of plasma obtained from obese and non-obese C57BL/6 donor mice on senescence and inflammation markers in recipient mice.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that plasma transfer from obese mice accelerates cellular aging in recipient mice. This research is relevant as it explores the mechanisms by which obesity may contribute to aging processes, potentially addressing root causes of age-related dysfunction.

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