Probiotic supplementation on cognitive and other aging-related physiological functions in middle-aged and older adults with mild cognitive impairment (PCAMCI): protocol for a randomized, triple-blinded, placebo-controlled trial.

Jiani Huang, Quan Zou, Yue Chen, Yutong Zuo, Berty Ruping Song, Shuning Li, Chuang Han, Haiyang Dong, Gongshang Liu, Zidong Zhao, Wei Wei, Zhongren Liu, Jinglei Chai, Sixin Xie, Yunxin Wang, Piao Hou, Xiang Gao, Liang Sun

Department of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Fudan University, 130 Dong'an Road, Shanghai, 200032, China.Department of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Fudan University, 130 Dong'an Road, Shanghai, 200032, China. · pubmed

Paper

Abstract

Emerging evidence suggests gut microbiota modulation may influence neurocognitive function through the gut-brain axis. Although preliminary studies indicate probiotics' potential benefits for mild cognitive impairment (MCI), well-designed randomized controlled trials remain limited. This protocol paper describes a rigorously designed, registered clinical trial investigating the effects of targeted probiotic supplementation on cognitive and physiological outcomes in MCI participants.

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Research summary

The paper investigates the effects of probiotic supplementation on cognitive and physiological outcomes in individuals with mild cognitive impairment. This research is relevant as it explores potential interventions that may influence cognitive decline, a significant aspect of aging and longevity.

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