β-Galactosidase-Cleavable Polymeric Senotherapeutics for Protein-Binding Photodynamic Senolysis.

Nawab Ali, Wenlong Huang, Jia Tian, Weian Zhang

Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, People's Republic of China. · pubmed

Paper

Abstract

Selective elimination of senescent cells (SnCs) through senolytic strategies can counteract the progression of age-related dysfunction, but achieving precise, broad-spectrum, and controllable senolysis remains challenging. Here, we report PG@FBC, a polymeric senotherapeutic that exploits senescence-associated β-galactosidase (SA-β-gal) to trigger supramolecular disassembly and controlled photosensitizer release, enabling photodynamic senolysis with real-time imaging. Briefly, PG@FBC is composed of an amphiphilic block copolymer, POEGMA-

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Research summary

The paper presents a novel polymeric senotherapeutic that utilizes β-galactosidase for targeted elimination of senescent cells. This research is relevant as it addresses a root cause of aging by focusing on the selective removal of senescent cells, which are implicated in age-related dysfunction.

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