Myeloid-Derived CD38 Mediates Age-Related Endometrial Aging Through NAD

Lun Hua, Luting Liu, Dengfeng Gao, Lulu Ma, Xianyang Jin, Liuyong Lu, Shangbo Tian, Xuemei Jiang, Chao Jin, Bin Feng, Lianqiang Che, Shengyu Xu, Yan Lin, Long Jin, Yong Zhuo, Mingzhou Li, De Wu

Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan, China.Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, Sichuan, China. · pubmed

Paper

Abstract

Against the backdrop of the global trend toward delayed childbearing, elucidating the mechanisms underlying uterine aging has emerged as a critical biomedical priority for addressing age-related implantation failure. Through unbiased global metabolomic profiling of peri-implantation uteri across different ages in mice, we identified nicotinamide adenine dinucleotide (NAD

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Research summary

The paper claims that myeloid-derived CD38 mediates age-related endometrial aging through NAD. This research addresses mechanisms of aging in the context of reproductive health, which is pertinent to understanding and potentially mitigating age-related decline in fertility.

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