Functional interplay between endoplasmic reticulum stress and mitochondrial activity in a post-ovulatory aging model of mouse oocytes.

Fumihiro Nakamura, Isao Takehara, Saki Hine, Midori Saito, Jun Matsukawa, Michi Nishi, Satoru Nagase

Department of Obstetrics and Gynecology, Faculty of Medicine, Yamagata University, 2-2-2, Iida-Nishi, Yamagata, 990-9585, Japan.Department of Obstetrics and Gynecology, Faculty of Medicine, Yamagata University, 2-2-2, Iida-Nishi, Yamagata, 990-9585, Japan. · pubmed

Paper

Abstract

To investigate whether targeting the ER-mitochondria axis can improve embryonic development in a post-ovulatory aging (POA) model by evaluating organelle-specific modulation.

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Research summary

Targeting the ER-mitochondria axis can improve embryonic development in a post-ovulatory aging model. The study addresses the interplay between cellular stress and mitochondrial function, which are critical factors in the aging process and may contribute to understanding mechanisms of reproductive aging.

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