Activation of aryl hydrocarbon receptor signaling by indole-3-lactic acid from Bacillus velezensis DS2 reinforces gut mucosal immunity and attenuates inflammaging in aged mice.
Abstract
Aging is characterized by progressive immunosenescence and inflammaging, in which impaired gut barrier and dysregulated mucosal immunity exacerbate systemic senescence. While probiotics modulate gut health, their role in mitigating age-related immune dysfunction via specific microbial metabolites remains unclear. This study aims to investigate the effects of Bacillus velezensis DS2, a novel probiotic, in alleviating inflammaging, with a focus on tryptophan-metabolic signaling and immune regulation.
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Research summary
The paper claims that activation of aryl hydrocarbon receptor signaling by indole-3-lactic acid from Bacillus velezensis DS2 can enhance gut mucosal immunity and reduce inflammaging in aged mice. This research addresses the underlying mechanisms of immunosenescence and gut health in the context of aging, which are critical factors in longevity.
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