From fat to fate: how aging adipose tissue drives systemic metabolic aging.

Haiyan Lin, Hongyu Li, Qiang Tang

Heilongjiang University of Traditional Chinese Medicine, No. 24 Heping Road, Xiangfang District, Harbin, Har, Heilongjiang Province, China. [email protected] University of Traditional Chinese Medicine, No. 24 Heping Road, Xiangfang District, Harbin, Har, Heilongjiang Province, China. [email protected]. · pubmed

Paper

Abstract

Aging adipose tissue is a consequence of organismal aging and an "amplifier" that drives systemic metabolic disorders. This review proposes the conceptual framework of the "aging metabolic amplifier", systematically explaining how aging adipose tissue reshapes the microenvironment of distant organs through its secretory profile, thereby linking obesity, diabetes, cardiovascular diseases, and neurodegenerative diseases. The concept of the "aging metabolic amplifier" emphasizes the important role of senescent adipocytes in systemic metabolic dysfunction, and systematically elaborates on their heterogeneous characteristics, autonomous and non-autonomous changes, as well as their mechanisms in ectopic lipid deposition, cardiovascular diseases, and cognitive decline. Currently, specific intervention strategies-such as activating the thermogenic program, eliminating senescent cells, regulating autophagy, and improving the microenvironment- have been proposed, providing potential therapeutic directions for delaying aging and related metabolic diseases.

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Research summary

Aging adipose tissue acts as a systemic metabolic amplifier that contributes to various age-related diseases. This paper is relevant as it addresses the mechanisms by which aging adipose tissue influences metabolic aging and proposes intervention strategies that target the root causes of aging-related metabolic dysfunction.

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