Isolation, purification, characterization and anti-aging potential of an extracellular polysaccharide AEPS-1 from Streptomyces sp. YJ06.

Yujuan Sun, Meiling Liu, Tengyu Wang, Minquan Du, Xinxin Cui, Tong Wu, Kun Yang, Xinwei Liu, Fengxia Sun

College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018, PR China. Electronic address: [email protected] of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018, PR China. Electronic address: [email protected]. · pubmed

Paper

Abstract

An extracellular polysaccharide (AEPS-1) with novel structure and anti-aging potential was isolated and characterized from Streptomyces sp. YJ06. Structural analysis revealed AEPS-1 is a neutral gluco-mannopolysaccharide of low molecular weight (8513 Da) featuring a unique triple-helical conformation and a highly branched architecture. It demonstrated significant in vitro antioxidant activity, characterized by exceptional reducing power alongside moderate free radical scavenging capacity. Crucially, AEPS-1 effectively extended the chronological lifespan of Saccharomyces cerevisiae by alleviating oxidative damage, as evidenced by reduced malondialdehyde (MDA) and enhanced superoxide dismutase (SOD) activity. This study highlights AEPS-1 as a promising candidate for further development as a natural anti-aging agent.

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Research summary

The paper claims that the extracellular polysaccharide AEPS-1 extends the lifespan of Saccharomyces cerevisiae by alleviating oxidative damage. This research is relevant as it explores a potential natural agent that may address mechanisms of aging through antioxidant activity, contributing to the understanding of lifespan extension.

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