Modeling Huntington's disease against age-related genes reveals

Maialen Arrieta-Lobo, Francesca Farina, Tamara Monteagudo Aboy, Megan Mair, Cloé Mendoza, Huy Tran, Jeff Aaronson, Jim Rosinski, Lisa Ellerby, Emmanuel Brouillet, Jean-Michel Peyrin, Juan Botas, Christian Neri, Lucile Megret

Not availableNot available · pubmed

Paper

Abstract

Neurons adapt gene expression to counter aging, yet the mechanisms by which they harness age- related genes to resist neurodegenerative disease remain elusive. We found that transcriptionalaging inversion (TAGI) in the

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that transcriptional aging inversion (TAGI) in neurons can help resist neurodegenerative diseases like Huntington's. This research explores mechanisms that could potentially address the root causes of aging-related neurodegeneration, making it relevant to longevity research.

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