Defining the marker and developmental trajectory of myeloid-derived suppressor cells in aging by single-cell transcriptomics.

Yaru Su, Ruimin Wu, Haochen Ai, Zhaoming Zhong, Lin Zou, Zihan Wang, Kewu Tu, Lingzheng Tang, Jiawen Gao, Yusheng Huang, Congrui Liao, Guanhai Zeng, Hongyang Zhang, Jian Jin, Siyuan Zhu

Department of Ophthalmology, Nanfang Hospital, Southern Medical University, Guangzhou, China.Department of Ophthalmology, Nanfang Hospital, Southern Medical University, Guangzhou, China. · pubmed

Paper

Abstract

Myeloid-derived suppressor cells (MDSCs) are recognized as a key mediator of immunosuppression in aging, which induce immunosenescence and increase elderly people's susceptibility to infections, cancers, autoimmune diseases, and degenerative diseases. However, the commonly used MDSC markers overlap with those defining healthy and normal neutrophils or monocytes, which makes it challenging to distinguish MDSCs from their myeloid counterparts, and hampers deeper understanding of the pathophysiological functions of MDSCs. In this study, we compared MDSCs from aged mice to young controls using single-cell RNA sequencing. We established MDSC-specific gene signature, which revealed the general characteristics of MDSCs during aging, and thus facilitating distinguishing them from normal myeloid cells. Experimental study revealed that CD300c may serve as a specific marker for improved detection and enrichment of MDSCs in aging. CD11b

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Research summary

The study identifies CD300c as a specific marker for myeloid-derived suppressor cells in aging. This research is relevant as it addresses the immunological changes associated with aging, which are critical for understanding the underlying mechanisms of age-related diseases and potential interventions.

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