Ginsenoside Rb1 attenuates arterial aging by reducing DNA damage in aged mice.

Qi Si, Lin Wu, Ximei Zhang, Guangyao Shi, Yingying Zhao, Yong Liu, Baoshun Hao, Shujie Yu, Bin Zhou, Yanling Zhang, Xiaoxian Qian, Dinghui Liu, Jianrui Zheng

Department of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.Department of Cardiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China. · pubmed

Paper

Abstract

Vascular aging is a critical risk factor for the development and progression of cardiovascular diseases. Age-related degenerative changes in vascular structure and function significantly promote the onset of various vascular disorders. Currently, the specific molecular mechanisms underlying age-associated vascular structural and functional decline have not been fully elucidated. Ginsenoside Rb1 (Rb1), as the primary active component of ginseng, has been confirmed to possess potential anti-aging properties. This study aims to investigate the protective effects of Rb1 on the aorta in aged mice and its underlying molecular mechanisms, thereby providing experimental evidence and theoretical support for the screening of natural anti-vascular aging drugs.

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Research summary

Ginsenoside Rb1 reduces DNA damage in aged mice, potentially attenuating arterial aging. The study addresses the underlying mechanisms of vascular aging, which is a critical aspect of longevity research.

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