Development and validation of a modified phenoage for biological aging and chronic diseases in a chinese cohort.

Jialiang Zheng, Tao Liu, Yumei Luo, Xing Wei

Yunnan University, Kunming, Yunnan, 650091, China. Electronic address: [email protected] University, Kunming, Yunnan, 650091, China. Electronic address: [email protected]. · pubmed

Paper

Abstract

To address the original PhenoAge's reliance on C-reactive protein (CRP)-a non-routine clinical biomarker-and enhance practical utility in routine healthcare settings, we developed a modified algorithm (PA-CRP) excluding CRP while retaining its core multi-omics integration framework, and further evaluated its associations with chronic diseases and lifestyle factors in a Chinese cohort.

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Research summary

The paper claims to have developed a modified algorithm for assessing biological aging that excludes CRP while maintaining a multi-omics approach. This research is relevant as it seeks to improve the assessment of biological aging, which is a fundamental aspect of longevity research and understanding age-related diseases.

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