Cellular senescence in giant cell arteritis and polymyalgia rheumatica: From mechanisms to therapeutic opportunities.

Yiting Luo, Fan Yang, Yanlin He, Jin Lin, Weiqian Chen

Division of Rheumatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. · pubmed

Paper

Abstract

Giant cell arteritis (GCA) and (PMR) are inflammatory rheumatic disorders whose pathogenesis are unclear. The interleukin (IL)-6 receptor inhibitor is the first approved biologic agent for GCA and PMR, reducing relapse rates and cumulative glucocorticoid (GC) doses. Notably, IL-6, also a key pro-inflammatory factor secreted by senescent cells, contributes to tissue aging and chronic inflammation. We aim to explore the role of senescence-associated secretory phenotype (SASP) in the pathogenesis of GCA and PMR.

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Research summary

The paper explores the role of senescence-associated secretory phenotype (SASP) in the pathogenesis of giant cell arteritis and polymyalgia rheumatica. This research is relevant as it investigates cellular senescence, a key mechanism in aging and chronic inflammation, which could lead to therapeutic opportunities that address the underlying processes of age-related diseases.

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