Facial skin aging: an integrative analysis of genetics, epigenetics, and lifestyle factors.

Rezvan Noroozi, Aleksandra Pisarek-Pacek, Bożena Wysocka, Kamila Migacz-Gruszka, Paulina Pruszkowska-Przybylska, Magdalena Kobus, Dagmara Lisman, Julia Zacharczuk, Joanna Rudnicka, Aleksandra Iljin, Kathryn C Fitzgerald, Małgorzata Michalczyk, Piotr Kaczka, Michał Krzysztofik, Maciej Kostrzewa, Aneta Sitek, Magdalena Spólnicka, Andrzej Ossowski, Wojciech Branicki, Ewelina Pośpiech

Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. · pubmed

Paper

Abstract

Facial wrinkling is a prominent sign of aging, yet individuals exhibit unique trajectories of biological aging, contributing to the variability in facial appearance. Here, we present a pioneering study exploring the association between lifestyle choices, DNA methylation, and SNP genotypes with a range of facial skin aging phenotypes. The study demonstrated that age-related facial skin phenotypes are influenced by multiple environmental stressors. Epigenome-wide association analyses identified differentially methylated cytosines mapped to 151 loci, including novel genes associated with facial wrinkles, such as EDAR (cg02925966, p = 4.96 × 10

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Research summary

The study claims that age-related facial skin phenotypes are influenced by genetics, epigenetics, and lifestyle factors. This research is relevant as it explores the biological mechanisms underlying aging, specifically in the context of facial skin, which may contribute to a broader understanding of aging processes.

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