Chirality-Governed Anti-Aging Effects of Carbon Dots in Caenorhabditis Elegans.

Mengling Zhang, Yurong Ma, Fan Liao, Huiwen Shu, Zeyu Wu, Hao Li, Hui Huang, Jian Huang, Yang Liu, Zhenhui Kang

State Key Laboratory of Bioinspired Interfacial Materials Science, Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu, China.State Key Laboratory of Bioinspired Interfacial Materials Science, Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu, China. · pubmed

Paper

Abstract

Anti-aging is crucial for facilitating immune modulation and promoting enhanced health management and quality of life among the elderly. This primarily focuses on enhancing the antioxidant defense system to repair damage related to aging. Here, we demonstrate the chirality-governed anti-aging effects of carbon dots (CDs) in Caenorhabditis elegans (C. elegans). Chiral CDs, namely, D-/L-CDs, with high antioxidant capacity are designed using machine learning, and the optimized versions exhibit broad-spectrum antioxidant activity in vitro. These chiral CDs can effectively protect cells from H

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Research summary

The paper claims that chiral carbon dots exhibit anti-aging effects in C. elegans through enhanced antioxidant activity. This research is relevant as it explores a potential intervention targeting the mechanisms of aging rather than merely addressing age-related diseases.

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