Senescent Mesenchymal Stromal Cells Differentially Alter Adipogenesis in Adipose Tissue, Skeletal Muscle, and Bone Marrow.

Xu Zhang, Madison L Doolittle, Ting Fan, Utkarsh Tripathi, Yan Er Ng, Xinyi Jiang, João F Passos, Diana Jurk, David G Monroe, Tamara Tchkonia, James L Kirkland, Paul D Robbins, Sundeep Khosla, Nathan K LeBrasseur

Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA. · pubmed

Paper

Abstract

Aging alters mesenchymal stromal cell (MSC) function, leading to dysregulated adipogenesis across tissues through biased lineage commitment. Fat redistribution from adipose depots to skeletal muscle and bone marrow is common in aging, but the underlying mechanisms remain unclear. This study investigates how MSC senescence modulates adipogenesis.

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Research summary

Senescent mesenchymal stromal cells alter adipogenesis in various tissues, contributing to fat redistribution associated with aging. This study addresses the mechanisms underlying age-related changes in MSC function, which is crucial for understanding the root causes of aging and potential interventions.

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