A conceptual model of oxygen-ozone therapy as a modulator of aging via the HMGB1 pathway.

Salvatore Chirumbolo, Luigi Valdenassi, Dario Bertossi, Fortunato Loprete, Umberto Tirelli, Marianno Franzini

Department of Engineering for Innovation Medicine, University of Verona, Strada Le Grazie 8, 37134, Verona, Italy. [email protected]. · pubmed

Paper

Abstract

To evaluate whether oxygen-ozone therapy (OOT) can modulate aging by inducing adaptive chaos in the HMGB1-Nrf2 redox-inflammatory pathway.

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Research summary

The paper proposes that oxygen-ozone therapy can modulate aging through the HMGB1-Nrf2 redox-inflammatory pathway. This research is relevant as it explores a potential intervention that targets mechanisms associated with aging rather than merely addressing age-related diseases.

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