Mitochondrial DNA copy number reduction via

Phyo W Win, Julia Nguyen, Elly H Shin, Tyler S Nagano, Brent Selimi, Katie Hong, Anahita M Meybodi, Bradley P Yates, Emma V Burke, David E Carter, Gregory A Newby, Charles Newcomb, Dan E Arking, Christina A Castellani

Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. · pubmed

Paper

Abstract

Mitochondrial DNA copy number (mtDNA-CN) is associated with several age-related chronic diseases and is a predictor of all-cause mortality. Here, we examine site-specific differential nuclear DNA (nDNA) methylation and differential gene expression resulting from in vitro reduction of mtDNA-CN to uncover shared genes and biological pathways mediating the effect of mtDNA-CN on disease.

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Research summary

The paper claims that site-specific differential nuclear DNA methylation and gene expression are influenced by the reduction of mitochondrial DNA copy number. This research is relevant as it explores the biological mechanisms linking mitochondrial function to age-related diseases, potentially addressing root causes of aging.

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