Food-derived antioxidant peptides mediated multifunctional bioactivities and bioavailability-enhancing delivery strategies via the Nrf2/Keap1 signaling pathway.

Wei Zhang, Shengbing Hu, Haiyan Tang, FeiFei Zhong, QinLu Lin, Wen Li, Jing Deng

National Engineering Research Center of Rice and Byproduct Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, China.National Engineering Research Center of Rice and Byproduct Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, China. · pubmed

Paper

Abstract

Antioxidant peptides are widely found in edible plant, animal and microbial resources, and their molecular weight, amino acid sequence, and spatial conformation determine antioxidant activity. They show great potential in the fields of anti-inflammation, anti-aging and neuroprotection by regulating the Nrf2/Keap1 signaling pathway. This review summarizes the latest research progress in the preparation of food-borne antioxidant peptides, focuses on the mechanism of action and structure-activity relationship of antioxidant peptides, the regulation of Nrf2/Keap1 pathway by antioxidant peptides to play various bioactive roles, and the research on the enhancement of bioavailability based on the methods of amino acid modification, nanocarriers (liposomes, chitosan), absorption enhancers, and emulsion. The study also provides an outlook on the multiple opportunities and challenges faced by food-borne antioxidant peptides. It is expected to provide a theoretical basis for the industrial development of functional foods related to antioxidant peptides.

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Research summary

The paper claims that food-derived antioxidant peptides can enhance bioavailability and exert multifunctional bioactivities through the Nrf2/Keap1 signaling pathway. This research is relevant as it explores mechanisms that may contribute to anti-aging effects and the potential for functional foods to address root causes of aging-related decline.

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