Identifying sex-specific biomarkers for intrinsic capacity decline in the aging population.

Lv-Tao Zeng, Ya-Qing Ma, Hong-Lei Liu, Jian-Ping Cai

Peking University Fifth School of Clinical Medicine, Beijing Hospital, Beijing, China.Peking University Fifth School of Clinical Medicine, Beijing Hospital, Beijing, China. · pubmed

Paper

Abstract

Intrinsic capacity (IC) decline is a key marker of aging-related functional loss, yet sex-specific biomarkers remain poorly characterized. This cross-sectional study of 1014 community-dwelling older adults investigated the associative strength and potential statistical intermediaries of insulin-like growth factor binding protein 2 (IGFBP2) and growth differentiation factor 15 (GDF-15) in IC impairment, with sex-stratified analyses.

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Research summary

The paper claims to identify sex-specific biomarkers associated with intrinsic capacity decline in older adults. This research is relevant as it seeks to understand biological markers that contribute to aging-related functional decline, which is a key aspect of longevity research.

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