Unveiling the protective effects of Cistanche phenylethanol glycosides against D-galactose-induced kidney aging: Insights from network pharmacology and transcriptomics.

Qianqian Wang, Chong Ma, Ruoyu Geng, Taotao Xue, Reziya Abula, Zixin Shen, Jianhua Yang, Junping Hu

College of Pharmacy, Xinjiang Medical University, Urumqi 830054, PR China. Electronic address: [email protected]. · pubmed

Paper

Abstract

The kidney, as a central metabolic organ, is highly susceptible to age-related deterioration. Over time, structural integrity progressively declines, leading to measurable reductions in renal function. Herba Cistanches, a well-known traditional anti-aging medicinal herb, is rich in phenylethanol glycosides (PhGs), which constitute its principal bioactive constituents. Despite its established pharmacological significance, the potential protective role of Cistanche phenylethanol glycosides (CPhGs) in mitigating kidney aging, along with the molecular mechanisms underlying such effects, remains insufficiently elucidated.

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Research summary

The paper claims that Cistanche phenylethanol glycosides can protect against kidney aging induced by D-galactose. This research addresses the potential protective mechanisms against age-related deterioration in kidney function, which is a relevant aspect of longevity research.

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