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RESEARCH PAPER / 2025-12-20

Association of plasma metabolites with epigenetic age acceleration: a two-sample Mendelian randomization study.

Hongyue Chen, Fengdan Wang, Yuangang Guo, Ying Zhu, Xiaotong Li, Zihan Meng, Xiaojing Feng, Yang Yang, Shangning Wu, Shufei Li, Bo Li

Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Xinmin Street No.1163, Changchun, 130021, China. · pubmed

Abstract

Epigenetic age acceleration (EAA) is a biomarker of biological aging associated with multiple diseases. Plasma metabolites are potential targets for disease prevention. Therefore, our study aims to investigate the association between plasma metabolites and EAA.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The study investigates the association between plasma metabolites and epigenetic age acceleration. This research is relevant as it explores potential biological markers and mechanisms related to aging, which could contribute to understanding and addressing the root causes of aging.

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