Epigenetic silencing of SPHK1-IRF7 axis drives inflammaging in age-related meniscus degeneration via sphingolipid-immune dysregulation.

Shunjie Yang, Hui Wang, Lingcheng Wang, Li Liu, Peng Xu, Xiaohe Tian, Gang Chen

Department of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, West China Hospital, Sichuan University, Chengdu, China.Department of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, West China Hospital, Sichuan University, Chengdu, China. · pubmed

Paper

Abstract

Age-related meniscus injury (MI) involves inflammaging, but biomarkers and mechanisms remain unclear.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that epigenetic silencing of the SPHK1-IRF7 axis contributes to inflammaging in age-related meniscus degeneration. This research addresses mechanisms underlying aging-related degeneration, which is pertinent to understanding and potentially mitigating age-related diseases.

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