Association of an inflammaging score based on IL-6, IL-10 and CXCL9, and frailty with long-term mortality in hospitalized older adults.

Matilde Sbriscia, Sonia Fantone, Mirko Di Rosa, Francesca Marchegiani, Rina Recchioni, Giulia Matacchione, Chiara Giordani, Francesco Piacenza, Robertina Giacconi, Davide Gentilini, Luciano Calzari, Carlo Fortunato, Gretta Veronica Badillo Pazmay, Monia Cecati, Sara Caccese, Emanuele Francini, Rosanna Maniscalco, Maurizio Cardelli, Elena Tortato, Federica Lenci, Yuri Rosati, Maurizio Burattini, Roberto Antonicelli, Andrea Corsonello, Luca Soraci, Leonardo Biscetti, Massimiliano Fedecostante, Riccardo Sarzani, Marco Malavolta, Tiziana Casoli, Maria Conte, Silvia Di Valerio, Angelica Giuliani, Antonio Domenico Procopio, Fabrizia Lattanzio, Anna Rita Bonfigli, Antonio Cherubini, Claudio Franceschi, Jacopo Sabbatinelli, Fabiola Olivieri

Advanced Technology Center for Aging Research and Geriatric Mouse Clinic, IRCCS INRCA, Ancona, Italy.Advanced Technology Center for Aging Research and Geriatric Mouse Clinic, IRCCS INRCA, Ancona, Italy. · pubmed

Paper

Abstract

Aging is accompanied by chronic low-grade inflammation ("inflammaging"), which contributes to increased morbidity and mortality in older adults. This study evaluated the prognostic value of circulating inflammatory biomarkers, i.e. interleukin-6 (IL-6), interleukin-10 (IL-10), and CXCL9, and their integration with frailty for long-term risk stratification.

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Research summary

The paper claims that an inflammaging score based on specific inflammatory biomarkers can predict long-term mortality in hospitalized older adults. This research is relevant as it explores the role of chronic inflammation in aging and its potential implications for longevity and age-related health outcomes.

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