Exercise mitigates high-fat diet-induced cardiac dysfunction via APOE genotype- and immune-dependent mechanisms: A photon-counting CT study in adult mice.

Rohan Nadkarni, Alex J Allphin, Darin P Clark, Yi Qi, Zay Yar Han, Ketan B Ghaghada, Alexandra Badea, Cristian T Badea

Quantitative Imaging and Analysis Lab, Department of Radiology, Duke University Medical Center, Durham, North Carolina, United States of America.Quantitative Imaging and Analysis Lab, Department of Radiology, Duke University Medical Center, Durham, North Carolina, United States of America. · pubmed

Paper

Abstract

Cardiovascular dysfunction frequently accompanies aging and is often worsened by adverse lifestyle factors and genetic susceptibility. The apolipoprotein E (APOE) gene modulates susceptibility to cardiovascular disease, but how exercise and diet interact with APOE genotype remains insufficiently understood. We investigate the cardioprotective potential of exercise in humanized APOE-targeted replacement mice on control and high-fat diet, using photon-counting computed tomography (PCCT) and deep learning-based image segmentation.

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Research summary

Exercise can mitigate cardiac dysfunction induced by a high-fat diet through mechanisms influenced by APOE genotype and immune response. The study addresses the interaction between lifestyle factors and genetic susceptibility in cardiovascular health, which is pertinent to understanding and potentially mitigating age-related diseases.

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