The Interplay of Genes and Environment Across Multiple Studies (IGEMS) Consortium After Fifteen Years.

Deborah Finkel, Brian K Finch, Margaret Gatz, Kaare Christensen, Carol E Franz, Ida K Karlsson, William S Kremen, Robert F Krueger, Michelle Lupton, Nicholas Martin, Matt McGue, Miriam A Mosing, Jenae Neiderhiser, Marianne Nygaard, Elizabeth Prom-Worley, Chandra Reynolds, Perminder Sachdev, Elina Sillanpää, Eero Vuoksimaa, Keith E Whitfield, Orla Hayden, Ellen Walters, Nancy L Pedersen

Center for Economic and Social Research, https://ror.org/03taz7m60University of Southern California, Los Angeles, California, USA.Center for Economic and Social Research, https://ror.org/03taz7m60University of Southern California, Los Angeles, California, USA. · pubmed

Paper

Abstract

The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 21 twin studies from 5 countries (Australia, Denmark, Finland, Sweden, and United States) established to explore the nature of gene-environment interplay in cognitive, physical, and emotional health across the adult lifespan. The combined data from over 145,000 participants (aged 18 to 108 years at intake) has supported multiple research projects over the three phases of development since its inception in 2010. Phases 1 and 2 focused on launching and growing the consortium and supported important developments in data harmonization, analyses of data pooled across multiple studies, incorporation of linkages to national registries and conscription data, and integration of molecular genetic and classical twin designs. IGEMS Phase 3 focuses on developing appropriate infrastructure to maximize utilization of this large twin consortium for aging research.

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Research summary

The paper claims that the IGEMS consortium has developed infrastructure to enhance research on gene-environment interplay in aging. This research is relevant as it explores the complex interactions between genetic and environmental factors that may influence aging processes and health outcomes across the lifespan.

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