Mesenchymal Clock Regulates TMJ Homeostasis and Lipid Metabolic Rhythms with Age.

S Cha, W Gao, J Wang, Z Tan, C Zhou, Q Zhao, D Bai

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu, China.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu, China. · pubmed

Paper

Abstract

Osteoarthritis (OA) is the most prevalent degenerative disorder of the temporomandibular joint (TMJ), with aging as a major risk factor. Although circadian clocks are essential for maintaining tissue homeostasis and metabolic balance, the influence of aging on tissue-specific circadian regulation of TMJ homeostasis remains unclear. Here, using aged mice and transgenic mouse models, we demonstrated that the mesenchymal circadian clock is indispensable for preserving TMJ osteochondral integrity during aging. Loss of the core circadian regulator

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that the mesenchymal circadian clock is essential for maintaining TMJ osteochondral integrity during aging. This research addresses the role of circadian rhythms in aging-related tissue homeostasis, which is relevant to understanding the mechanisms of aging and potential interventions.

Author of this paper? Send a correction.