Synergistic effects of multicomponent exercise and rTMS on sarcopenia and mild cognitive impairment in older people: a protocol for a randomized controlled trial.

Yanqing Ren, Xiangfeng He, Zhen Zhang, Min Zhuang, Gonghua Yin, Lingyan Huang, Nan Chen

Department of Rehabilitation, Chongming Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, China.Department of Rehabilitation, Chongming Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, China. · pubmed

Paper

Abstract

Sarcopenia and cognitive impairment (CI) are major contributors to disability in older people, significantly reducing quality of life and imposing a substantial burden on healthcare systems. Sarcopenia accelerates cognitive decline through mechanisms such as chronic inflammation, mitochondrial dysfunction, and disruption of the muscle-brain axis. Conversely, CI impairs motor planning and daily functioning, further exacerbating muscle loss and physical deterioration. Previous studies have shown that physical exercise optimizes peripheral physiological conditions, promoting neuroplasticity in the central nervous system. Similarly, repetitive transcranial magnetic stimulation (rTMS) enhances brain plasticity, improving both cognitive and physical functions. This study aims to evaluate the combined effects of multicomponent exercise and rTMS on sarcopenia and CI in older people.

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Research summary

The study aims to evaluate the combined effects of multicomponent exercise and rTMS on sarcopenia and cognitive impairment in older people. This research addresses age-related conditions that contribute to disability and poor quality of life, which are critical factors in longevity and healthy aging.

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