Dietary kaempferol attenuates aging-related cognitive decline through gut microbiota modulation and intestinal barrier strengthening with suppression of neuroinflammation in mice.

Xintong Wang, Wen Zhang, Huihui Wang, Yuzhen Zhao, Pengjie Wang, Ran Wang, Yanan Sun, Fazheng Ren, Yixuan Li

Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100083, China.Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100083, China. · pubmed

Paper

Abstract

Kaempferol, a natural dietary flavonoid, has shown neuroprotective potential. However, its mechanisms of protection against age-related cognitive decline, especially those mediated

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Dietary kaempferol improves cognitive function in aging mice by modulating gut microbiota and reducing neuroinflammation. This research addresses mechanisms that may contribute to age-related cognitive decline, aligning with the goal of understanding and potentially mitigating the root causes of aging.

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