The Role of Sirtuins in Improving Cardiovascular Function and the Prevention of Aging.

Rubi Duran, Manish A Parikh, Amit Raizada, William H Frishman, Stephen J Peterson

From the Department of Medicine, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY.From the Department of Medicine, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY. · pubmed

Paper

Abstract

The prevalence of cardiovascular disease increases with age, driven by processes of inflammation, oxidative stress, and mitochondrial dysfunction. Delaying the cascade caused by these risk factors will be essential to reducing cardiovascular morbidity and mortality in our aging population. Sirtuins are nicotinamide adenine dinucleotide-dependent deacetylase enzymes involved in metabolic regulation that show promise in attenuating these disease processes and increasing longevity. This review will examine the role of sirtuins at the cellular level in relation to cardiovascular health and discuss their potential as novel therapeutic targets for atherosclerosis, heart failure, and metabolic syndrome.

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Research summary

Sirtuins play a crucial role in improving cardiovascular function and may serve as therapeutic targets for age-related cardiovascular diseases. The paper addresses mechanisms that could potentially mitigate aging processes, aligning with longevity research.

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