Vitamin D3 supplementation reverses aging-related changes in cholinergic functions and improves spatial memory in aged rats.

Elif Aksoz, Medine Karabulut, Mustafa Hilmi Yaranoğlu

Balikesir University, Faculty of Medicine, Department of Medical Pharmacology, Cagis Campus, Balikesir, Turkey. Electronic address: [email protected] University, Faculty of Medicine, Department of Medical Pharmacology, Cagis Campus, Balikesir, Turkey. Electronic address: [email protected]. · pubmed

Paper

Abstract

Dietary intake and synthesis of vitamin D synthesis decline with age, increasing the risk of vitamin D deficiency. Dementia and Alzheimer's disease development are closely linked to vitamin D deficiency. In this study, we investigated whether vitamin D supplementation could attenuate age-related effects on memory and the hippocampal cholinergic system in aged rats.

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Research summary

Vitamin D3 supplementation can reverse aging-related changes in cholinergic functions and improve spatial memory in aged rats. The study addresses the potential of vitamin D to mitigate age-related cognitive decline, which is a significant aspect of longevity research.

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